RAxML-NG v. 1.0.2 released on 22.02.2021 by The Exelixis Lab. Developed by: Alexey M. Kozlov and Alexandros Stamatakis. Contributors: Diego Darriba, Tomas Flouri, Benoit Morel, Sarah Lutteropp, Ben Bettisworth. Latest version: https://github.com/amkozlov/raxml-ng Questions/problems/suggestions? Please visit: https://groups.google.com/forum/#!forum/raxml System: Intel(R) Xeon(R) Gold 6140 CPU @ 2.30GHz, 36 cores, 251 GB RAM RAxML-NG was called at 03-Jun-2021 14:47:49 as follows: raxml-ng --ancestral --msa /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P01308/2_msa/P01308_nogap_msa.fasta --tree /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P01308/3_mltree/P01308.raxml.bestTree_unrooted --model LG4X --prefix /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P01308/4_raxmlng_ancestral/P01308 --threads 4 Analysis options: run mode: Ancestral state reconstruction start tree(s): user random seed: 1622720869 tip-inner: ON pattern compression: OFF per-rate scalers: OFF site repeats: OFF branch lengths: proportional (ML estimate, algorithm: NR-FAST) SIMD kernels: AVX2 parallelization: coarse-grained (auto), PTHREADS (4 threads), thread pinning: OFF [00:00:00] Reading alignment from file: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P01308/2_msa/P01308_nogap_msa.fasta [00:00:00] Loaded alignment with 268 taxa and 110 sites WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A0Q3X9B0_A0A0Q3X9B0_AMAAE_12930 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A091IS51_A0A091IS51_EGRGA_188379 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A091W703_A0A091W703_NIPNI_128390 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A087RJL1_A0A087RJL1_APTFO_9233 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A093HWM4_A0A093HWM4_STRCA_441894 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A091VH88_A0A091VH88_OPIHO_30419 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A099ZWK7_A0A099ZWK7_TINGU_94827 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A091G467_A0A091G467_9AVES_55661 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A0A0ANY6_A0A0A0ANY6_CHAVO_50402 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A2I0MK45_A0A2I0MK45_COLLI_8932 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A093IBU7_A0A093IBU7_DRYPU_118200 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A091I6R2_A0A091I6R2_CALAN_9244 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A1V4K7V7_A0A1V4K7V7_PATFA_372326 are exactly identical! WARNING: Sequences sp_P18254_IGF1_CHICK_9031 and tr_A0A218UWW6_A0A218UWW6_9PASE_299123 are exactly identical! WARNING: Sequences tr_M3Y2P9_M3Y2P9_MUSPF_9669 and tr_J9P961_J9P961_CANLF_9615 are exactly identical! WARNING: Sequences tr_M3Y2P9_M3Y2P9_MUSPF_9669 and tr_G1L5W6_G1L5W6_AILME_9646 are exactly identical! WARNING: Sequences tr_M3Y2P9_M3Y2P9_MUSPF_9669 and tr_A0A2I2UMR3_A0A2I2UMR3_FELCA_9685 are exactly identical! WARNING: Sequences tr_M3Y2P9_M3Y2P9_MUSPF_9669 and tr_A0A2Y9JPY2_A0A2Y9JPY2_ENHLU_391180 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_A0A2I2ZL48_A0A2I2ZL48_GORGO_9595 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_H2NCF8_H2NCF8_PONAB_9601 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_A0A2I3SPQ3_A0A2I3SPQ3_PANTR_9598 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_I3N2V4_I3N2V4_ICTTR_43179 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_A0A286XQQ0_A0A286XQQ0_CAVPO_10141 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and sp_Q08279_IGF2_CAVPO_10141 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and sp_P01344_IGF2_HUMAN_9606 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_A0A1D5R7J7_A0A1D5R7J7_MACMU_9544 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_G5C2F3_G5C2F3_HETGA_10181 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_G7PNW7_G7PNW7_MACFA_9541 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_A0A096MVH6_A0A096MVH6_PAPAN_9555 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_A0A091DB43_A0A091DB43_FUKDA_885580 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_A0A2K5NSA8_A0A2K5NSA8_CERAT_9531 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_A0A2K6CQS4_A0A2K6CQS4_MACNE_9545 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_A0A2K5XCI6_A0A2K5XCI6_MANLE_9568 are exactly identical! WARNING: Sequences tr_A0A2I3GG72_A0A2I3GG72_NOMLE_61853 and tr_A0A2R9B770_A0A2R9B770_PANPA_9597 are exactly identical! WARNING: Sequences sp_Q6YK33_INS_GORGO_9595 and sp_P01308_INS_HUMAN_9606 are exactly identical! WARNING: Sequences tr_A0A3B5QFU1_A0A3B5QFU1_XIPMA_8083 and tr_A0A087Y814_A0A087Y814_POEFO_48698 are exactly identical! WARNING: Sequences tr_A0A3B5QM20_A0A3B5QM20_XIPMA_8083 and tr_A0A087YIN9_A0A087YIN9_POEFO_48698 are exactly identical! WARNING: Sequences tr_G7NBL9_G7NBL9_MACMU_9544 and tr_G7PNW8_G7PNW8_MACFA_9541 are exactly identical! WARNING: Sequences tr_H0ZM10_H0ZM10_TAEGU_59729 and tr_U3K384_U3K384_FICAL_59894 are exactly identical! WARNING: Sequences tr_H0ZM10_H0ZM10_TAEGU_59729 and tr_A2IT63_A2IT63_ANAPL_8839 are exactly identical! WARNING: Sequences tr_H0ZM10_H0ZM10_TAEGU_59729 and tr_A0A091EW35_A0A091EW35_CORBR_85066 are exactly identical! WARNING: Sequences tr_A0A337SBX1_A0A337SBX1_FELCA_9685 and sp_P06306_INS_FELCA_9685 are exactly identical! WARNING: Sequences tr_A0A0D9RBQ0_A0A0D9RBQ0_CHLSB_60711 and tr_A0A2K5YKV7_A0A2K5YKV7_MANLE_9568 are exactly identical! WARNING: Sequences tr_A0A151MC98_A0A151MC98_ALLMI_8496 and tr_A0A3Q0HL91_A0A3Q0HL91_ALLSI_38654 are exactly identical! WARNING: Sequences tr_A0A151NI81_A0A151NI81_ALLMI_8496 and tr_K7SEB5_K7SEB5_ALLSI_38654 are exactly identical! WARNING: Sequences tr_A0A091EBY6_A0A091EBY6_CORBR_85066 and tr_A0A093PRC8_A0A093PRC8_9PASS_328815 are exactly identical! WARNING: Sequences tr_A0A091EBY6_A0A091EBY6_CORBR_85066 and tr_A0A091UJ82_A0A091UJ82_NIPNI_128390 are exactly identical! WARNING: Sequences tr_A0A091EBY6_A0A091EBY6_CORBR_85066 and tr_A0A087RK38_A0A087RK38_APTFO_9233 are exactly identical! WARNING: Sequences tr_A0A091EBY6_A0A091EBY6_CORBR_85066 and tr_A0A091XDC3_A0A091XDC3_OPIHO_30419 are exactly identical! WARNING: Sequences tr_A0A091EBY6_A0A091EBY6_CORBR_85066 and tr_A0A091FN27_A0A091FN27_9AVES_55661 are exactly identical! WARNING: Sequences tr_A0A091EBY6_A0A091EBY6_CORBR_85066 and tr_A0A0A0AY17_A0A0A0AY17_CHAVO_50402 are exactly identical! WARNING: Sequences tr_A0A2I0MHN3_A0A2I0MHN3_COLLI_8932 and tr_A0A1V4JNL6_A0A1V4JNL6_PATFA_372326 are exactly identical! WARNING: Sequences tr_A4GUE9_A4GUE9_SALSA_8030 and tr_C6GBY8_C6GBY8_ONCMY_8022 are exactly identical! WARNING: Sequences tr_A0A1V4JNK4_A0A1V4JNK4_PATFA_372326 and tr_A0A226N8C3_A0A226N8C3_CALSU_9009 are exactly identical! WARNING: Sequences tr_A0A2U4BNR4_A0A2U4BNR4_TURTR_9739 and tr_A0A2Y9PND8_A0A2Y9PND8_DELLE_9749 are exactly identical! WARNING: Sequences tr_A0A2Y9FWL7_A0A2Y9FWL7_PHYCD_9755 and tr_A0A383YSK5_A0A383YSK5_BALAS_310752 are exactly identical! WARNING: Duplicate sequences found: 56 NOTE: Reduced alignment (with duplicates and gap-only sites/taxa removed) NOTE: was saved to: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P01308/4_raxmlng_ancestral/P01308.raxml.reduced.phy Alignment comprises 1 partitions and 110 sites Partition 0: noname Model: LG4X+R4 Alignment sites: 110 Gaps: 21.57 % Invariant sites: 0.00 % NOTE: Binary MSA file created: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P01308/4_raxmlng_ancestral/P01308.raxml.rba Parallelization scheme autoconfig: 1 worker(s) x 4 thread(s) Parallel reduction/worker buffer size: 1 KB / 0 KB [00:00:00] Loading user starting tree(s) from: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P01308/3_mltree/P01308.raxml.bestTree_unrooted [00:00:00] Data distribution: max. partitions/sites/weight per thread: 1 / 28 / 2240 [00:00:00] Data distribution: max. searches per worker: 1 Starting ML tree search with 1 distinct starting trees [00:00:00] Tree #1, initial LogLikelihood: -24820.076833 [00:00:00 -24820.076833] Initial branch length optimization [00:00:00 -14589.219944] Model parameter optimization (eps = 0.100000) [00:00:05] Tree #1, final logLikelihood: -14376.796869 Optimized model parameters: Partition 0: noname Rate heterogeneity: FREE (4 cats, mean), weights&rates: (0.169712,0.141817) (0.171749,1.271727) (0.324961,0.405164) (0.333578,1.876178) Base frequencies (model): M0: 0.147383 0.017579 0.058208 0.017707 0.026331 0.041582 0.017494 0.027859 0.011849 0.076971 0.147823 0.019535 0.037132 0.029940 0.008059 0.088179 0.089653 0.006477 0.032308 0.097931 M1: 0.063139 0.066357 0.011586 0.066571 0.010800 0.009276 0.053984 0.146986 0.034214 0.088822 0.098196 0.032390 0.021263 0.072697 0.016761 0.020711 0.020797 0.025463 0.045615 0.094372 M2: 0.062457 0.066826 0.049332 0.065270 0.006513 0.041231 0.058965 0.080852 0.028024 0.037024 0.075925 0.064131 0.019620 0.028710 0.104579 0.056388 0.062027 0.008241 0.033124 0.050760 M3: 0.106471 0.074171 0.044513 0.096390 0.002148 0.066733 0.158908 0.037625 0.020691 0.014608 0.028797 0.105352 0.007864 0.007477 0.083595 0.055726 0.047711 0.003975 0.010088 0.027159 Substitution rates (model): M 0: 0.295719 0.067388 0.253712 1.029289 0.107964 0.514644 10.868848 0.380498 0.084223 0.086976 0.188789 0.286389 0.155567 1.671061 2.132922 0.529591 0.115551 0.102453 0.916683 0.448317 0.457483 0.576016 1.741924 0.736017 0.704334 5.658311 0.123387 0.221777 93.433377 0.382175 0.235965 6.535048 0.525521 0.303537 0.641259 0.289466 0.102065 2.358429 0.251987 0.216561 0.503084 0.435271 4.873453 0.090748 0.033310 0.746537 0.128905 0.127321 0.904011 0.939733 0.435450 0.046646 0.262076 0.043986 0.189008 0.599450 109.901504 1.070052 5.229858 0.052764 0.021407 0.621146 0.081091 0.205164 5.164456 0.747330 0.308078 0.260889 0.185083 0.080708 0.029955 0.084794 1.862626 0.553477 0.151733 0.230320 0.096955 0.352526 0.590018 0.386853 1.559564 0.606648 0.587531 0.592318 0.885230 4.117654 0.246260 6.508329 0.054187 0.195703 1.669092 0.810168 0.066081 2.437439 0.165666 0.106333 0.093417 0.035149 0.072549 1.202023 1.634845 0.060194 0.069359 2.448827 0.232297 0.064822 3.537387 0.435384 0.290413 0.280695 0.105999 0.206603 0.404968 0.048984 0.069963 0.256662 0.228519 0.241077 4.320442 3.656545 0.290216 0.307466 0.096556 0.306067 0.204296 0.504221 1.991533 0.655465 6.799829 11.291065 0.961142 0.448965 6.227274 20.304886 0.205944 1.495537 0.091940 1.994320 0.754940 0.170343 0.050315 0.372166 0.206332 0.097050 5.381403 0.122332 3.256485 2.261319 0.848067 0.064441 0.102493 0.459041 0.133091 0.561215 0.457430 0.163849 5.260446 0.360946 0.389413 0.033291 0.115301 0.112593 1.559944 0.426508 0.132547 0.498634 0.559069 0.264728 0.693307 0.438856 0.306683 0.109129 18.392863 66.647302 0.400021 4.586081 2.099355 0.411347 0.476350 0.584622 3.634276 0.101797 0.148995 0.089177 0.034710 0.063603 0.755865 20.561407 0.133790 0.154902 M 1: 0.066142 0.590377 0.069930 9.850951 1.101363 0.150375 0.568586 0.051668 0.127170 0.292429 0.071458 1.218562 0.075144 7.169085 30.139501 13.461692 0.021372 0.045779 4.270235 0.468325 0.013688 0.302287 1.353957 0.028386 0.037750 0.262130 0.016923 0.064289 0.855973 0.079621 0.011169 0.161937 0.276530 0.161053 0.081472 0.036742 0.030342 2.851667 3.932151 8.159169 0.219934 0.421974 2.468752 0.344765 0.210724 1.172204 0.763553 0.082464 0.726566 11.149790 4.782635 0.058046 0.498072 0.258487 0.146882 0.249672 0.560142 0.046719 0.106259 0.003656 0.004200 0.014189 0.009876 0.002656 0.040244 0.267322 0.053740 0.006597 0.027639 0.012745 0.582670 0.005035 0.275844 0.098208 0.445038 1.217010 0.033969 1.988516 0.681161 0.825960 18.762977 11.949233 0.286794 0.534219 4.336817 3.054085 0.129551 4.210126 0.165753 1.088704 1.889645 3.344809 0.111063 2.067758 3.547017 2.466507 0.188236 0.203493 0.281953 0.037250 0.029788 0.008541 0.014768 0.125869 0.056702 0.004186 0.110993 0.201148 0.139705 0.009201 0.012095 0.043812 0.013513 0.002533 0.005848 0.031390 0.021612 0.004854 0.129497 0.976631 0.053397 0.019475 0.004964 0.015539 0.031779 0.064558 0.065585 0.079927 0.095591 0.196886 0.408834 0.126088 0.037226 0.452302 0.016212 7.278994 0.029917 7.918203 0.450964 0.169797 0.104288 1.578530 0.015909 0.094365 16.179952 0.042762 14.799537 1.506485 0.637893 0.123793 0.641351 0.154810 0.140750 3.416059 0.259400 0.009457 0.090576 0.292108 0.297913 0.017172 0.021976 0.032578 1.375871 0.457399 0.598048 4.418398 0.239749 0.168432 2.950318 0.143327 0.328689 0.125011 0.562720 1.414883 0.227807 3.478333 2.984862 0.061299 0.077470 1.050562 13.974326 0.154326 0.224675 0.112000 0.060703 0.123480 5.294490 0.447011 0.033381 0.045528 M 2: 0.733336 0.558955 0.503360 4.149599 1.415369 1.367574 1.263002 0.994098 0.517204 0.775054 0.763094 1.890137 0.540460 0.200122 4.972745 1.825593 0.450842 0.526135 3.839269 0.597671 0.058964 2.863355 2.872594 0.258365 0.366868 2.578946 0.358350 0.672023 5.349861 0.691594 0.063347 0.032875 0.821562 0.580847 0.661866 0.265730 0.395134 5.581680 1.279881 1.335650 0.397108 1.840061 5.739035 0.284730 0.109781 1.612642 0.466979 0.141582 0.019509 4.670980 1.967383 0.088064 0.581928 0.145401 0.225860 0.434096 2.292917 1.024707 0.821921 0.027824 0.021443 0.088850 0.060820 0.018288 0.042687 1.199607 0.420710 0.037642 0.141233 0.090101 1.043232 0.209978 0.823594 3.039380 1.463390 1.983693 0.397640 2.831098 4.102068 0.059723 5.901348 2.034980 2.600668 5.413080 4.193725 4.534772 0.377181 4.877840 0.370939 1.298542 3.509873 2.646440 0.087872 0.072299 1.139018 0.864479 0.390688 0.322761 0.625409 0.496780 0.532488 0.232460 0.169219 0.755219 0.379926 0.020447 0.023282 0.503875 0.577513 0.109318 0.153776 0.696533 0.398817 0.008940 0.043707 0.436013 0.087640 0.064863 0.036426 1.673207 0.124068 0.218118 0.039217 0.104335 0.349195 0.838324 0.888693 0.488389 1.385133 0.050226 0.962470 0.502294 1.065585 8.351808 0.377304 5.102837 0.561690 7.010411 3.054968 0.039318 0.204155 2.653232 0.564368 0.854294 15.559906 0.401070 8.929538 5.525874 0.067505 0.273372 0.437116 1.927515 0.940458 2.508169 1.357738 0.043394 0.023126 0.567639 1.048288 0.120994 0.180650 0.449074 3.135353 0.012695 0.570771 2.319555 1.856122 0.975427 3.404087 0.015631 0.458799 0.151684 4.154750 11.429924 1.457957 0.233109 0.077004 0.011074 0.026268 0.052132 8.113282 0.377578 0.429221 0.260296 0.222293 0.273138 2.903836 4.731579 0.564762 0.681215 M 3: 0.658412 0.566269 0.854111 0.884454 1.309554 1.272639 1.874713 0.552007 0.227683 0.581512 0.695190 0.967985 0.344015 0.978992 3.427163 2.333253 0.154701 0.221089 2.088785 0.540749 0.058015 5.851132 2.294145 0.182966 0.684164 3.192521 0.528161 1.128882 3.010922 1.012866 0.227296 0.156635 0.878405 0.802754 0.830884 0.431617 0.456530 3.060574 1.279257 1.438430 0.431464 2.075952 4.840271 0.644656 0.266076 2.084975 0.720060 0.291854 0.028961 4.071574 2.258357 0.073037 1.238426 0.199728 0.160296 0.482619 2.992763 1.296206 0.841829 0.031467 0.048542 0.132774 0.133055 0.056045 0.209188 0.925172 0.360522 0.094591 0.313945 0.118104 0.992259 0.086318 2.149634 5.103188 3.775817 3.954021 0.190734 1.776095 4.495841 0.264277 7.063879 2.221150 3.017954 8.558815 4.310199 2.130054 0.571406 4.137385 0.437589 2.071689 2.498630 1.763546 0.116381 0.296578 1.033710 1.283423 0.312579 0.305772 0.681277 0.507160 0.351381 0.189152 0.217780 0.767361 0.278392 0.092075 0.177263 0.451893 0.653836 0.074620 0.181992 0.752277 0.679853 0.025780 0.082005 0.326441 0.343977 0.195877 0.217424 3.057583 0.377558 0.401252 0.072258 0.241015 0.665865 1.266791 0.680174 0.717301 4.001286 0.362942 1.189259 0.964545 1.350568 12.869737 0.531100 8.904999 0.652629 10.091413 2.671718 0.086367 0.359932 4.797423 0.336801 1.021885 23.029406 0.440178 14.013035 5.069337 0.539010 0.742569 0.780580 1.331875 1.531589 4.414850 1.082703 0.091278 0.172734 0.693405 1.422571 0.068958 0.163829 0.481711 4.643214 0.121821 0.584083 4.216178 1.677263 1.575754 5.046403 0.161015 1.531223 0.599244 5.832025 33.873091 1.914768 1.287474 0.444362 0.076328 0.079916 0.466823 5.231362 0.548763 0.831890 0.382271 0.208791 0.307846 3.717971 5.910440 0.282540 0.964421 Marginal ancestral probabilities saved to: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P01308/4_raxmlng_ancestral/P01308.raxml.ancestralProbs Reconstructed ancestral sequences saved to: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P01308/4_raxmlng_ancestral/P01308.raxml.ancestralStates Node-labeled tree saved to: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P01308/4_raxmlng_ancestral/P01308.raxml.ancestralTree Execution log saved to: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P01308/4_raxmlng_ancestral/P01308.raxml.log Analysis started: 03-Jun-2021 14:47:49 / finished: 03-Jun-2021 14:47:56 Elapsed time: 6.244 seconds