RAxML-NG v. 1.0.2 released on 22.02.2021 by The Exelixis Lab. Developed by: Alexey M. Kozlov and Alexandros Stamatakis. Contributors: Diego Darriba, Tomas Flouri, Benoit Morel, Sarah Lutteropp, Ben Bettisworth. Latest version: https://github.com/amkozlov/raxml-ng Questions/problems/suggestions? Please visit: https://groups.google.com/forum/#!forum/raxml System: Intel(R) Xeon(R) Gold 6140 CPU @ 2.30GHz, 36 cores, 251 GB RAM RAxML-NG was called at 04-Jun-2021 14:18:46 as follows: raxml-ng --ancestral --msa /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P00387/2_msa/P00387_nogap_msa.fasta --tree /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P00387/3_mltree/P00387.raxml.bestTree_unrooted --model LG4X --prefix /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P00387/4_raxmlng_ancestral/P00387 --threads 4 Analysis options: run mode: Ancestral state reconstruction start tree(s): user random seed: 1622805526 tip-inner: ON pattern compression: OFF per-rate scalers: OFF site repeats: OFF branch lengths: proportional (ML estimate, algorithm: NR-FAST) SIMD kernels: AVX2 parallelization: coarse-grained (auto), PTHREADS (4 threads), thread pinning: OFF [00:00:00] Reading alignment from file: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P00387/2_msa/P00387_nogap_msa.fasta [00:00:00] Loaded alignment with 1001 taxa and 301 sites WARNING: Sequences tr_G3QR02_G3QR02_GORGO_9595 and tr_K7CTG0_K7CTG0_PANTR_9598 are exactly identical! WARNING: Sequences tr_G3QR02_G3QR02_GORGO_9595 and sp_Q9UHQ9_NB5R1_HUMAN_9606 are exactly identical! WARNING: Sequences tr_G3QR02_G3QR02_GORGO_9595 and tr_A0A2R9AY08_A0A2R9AY08_PANPA_9597 are exactly identical! WARNING: Sequences tr_K7D4S0_K7D4S0_PANTR_9598 and tr_A0A2R9AW66_A0A2R9AW66_PANPA_9597 are exactly identical! WARNING: Sequences tr_B0W2L8_B0W2L8_CULQU_7176 and tr_B0WWN2_B0WWN2_CULQU_7176 are exactly identical! WARNING: Sequences tr_K4D6I5_K4D6I5_SOLLC_4081 and sp_P17570_NIA_SOLLC_4081 are exactly identical! WARNING: Sequences tr_A0A0E0FUV5_A0A0E0FUV5_ORYNI_4536 and tr_A2WWB5_A2WWB5_ORYSI_39946 are exactly identical! WARNING: Sequences tr_A0A0E0FUV5_A0A0E0FUV5_ORYNI_4536 and tr_I1NSN6_I1NSN6_ORYGL_4538 are exactly identical! WARNING: Sequences tr_A0A0E0FUV5_A0A0E0FUV5_ORYNI_4536 and tr_A0A0E0C9G3_A0A0E0C9G3_9ORYZ_40149 are exactly identical! WARNING: Sequences tr_A0A0E0FUV5_A0A0E0FUV5_ORYNI_4536 and tr_A0A0D3EVF0_A0A0D3EVF0_9ORYZ_65489 are exactly identical! WARNING: Sequences tr_A0A0E0FUV5_A0A0E0FUV5_ORYNI_4536 and tr_A0A0D9YGF3_A0A0D9YGF3_9ORYZ_40148 are exactly identical! WARNING: Sequences tr_A0A0E0FUV5_A0A0E0FUV5_ORYNI_4536 and tr_Q5N760_Q5N760_ORYSJ_39947 are exactly identical! WARNING: Sequences tr_A0A0E0GDD5_A0A0E0GDD5_ORYNI_4536 and tr_B8AJ60_B8AJ60_ORYSI_39946 are exactly identical! WARNING: Sequences tr_A0A0E0GDD5_A0A0E0GDD5_ORYNI_4536 and tr_A0A0E0NLH4_A0A0E0NLH4_ORYRU_4529 are exactly identical! WARNING: Sequences tr_A0A0E0ID59_A0A0E0ID59_ORYNI_4536 and sp_P16081_NIA1_ORYSJ_39947 are exactly identical! WARNING: Sequences tr_A0A0E0ID59_A0A0E0ID59_ORYNI_4536 and tr_Q6ZC33_Q6ZC33_ORYSJ_39947 are exactly identical! WARNING: Sequences tr_A0A1D5R848_A0A1D5R848_MACMU_9544 and tr_G8F667_G8F667_MACFA_9541 are exactly identical! WARNING: Sequences tr_A0A1D5R848_A0A1D5R848_MACMU_9544 and tr_A0A2I3M0J6_A0A2I3M0J6_PAPAN_9555 are exactly identical! WARNING: Sequences tr_A0A1D5R848_A0A1D5R848_MACMU_9544 and tr_A0A0D9RP34_A0A0D9RP34_CHLSB_60711 are exactly identical! WARNING: Sequences tr_A0A1D5R848_A0A1D5R848_MACMU_9544 and tr_A0A2K5L579_A0A2K5L579_CERAT_9531 are exactly identical! WARNING: Sequences tr_A0A1D5R848_A0A1D5R848_MACMU_9544 and tr_A0A2K6E3K0_A0A2K6E3K0_MACNE_9545 are exactly identical! WARNING: Sequences tr_A0A1D5R848_A0A1D5R848_MACMU_9544 and tr_A0A2K5ZBP4_A0A2K5ZBP4_MANLE_9568 are exactly identical! WARNING: Sequences tr_A0A2K1JYE3_A0A2K1JYE3_PHYPA_3218 and tr_Q4LEW9_Q4LEW9_PHYPA_3218 are exactly identical! WARNING: Sequences tr_I1P4P3_I1P4P3_ORYGL_4538 and tr_A0A0D3FB03_A0A0D3FB03_9ORYZ_65489 are exactly identical! WARNING: Sequences tr_A0A0E0PP91_A0A0E0PP91_ORYRU_4529 and tr_Q6AVN1_Q6AVN1_ORYSJ_39947 are exactly identical! WARNING: Sequences tr_E3LUT1_E3LUT1_CAERE_31234 and tr_A0A261BXX5_A0A261BXX5_9PELO_1503980 are exactly identical! WARNING: Sequences tr_F2SL72_F2SL72_TRIRC_559305 and tr_A0A059J8L7_A0A059J8L7_9EURO_1215338 are exactly identical! WARNING: Sequences tr_B3RLU5_B3RLU5_TRIAD_10228 and tr_A0A369SJJ9_A0A369SJJ9_9METZ_287889 are exactly identical! WARNING: Sequences tr_G3XTG4_G3XTG4_ASPNA_380704 and tr_A0A319AJ85_A0A319AJ85_9EURO_1450533 are exactly identical! WARNING: Sequences tr_G5E5N5_G5E5N5_BOVIN_9913 and sp_Q3MHW9_NB5R1_BOVIN_9913 are exactly identical! WARNING: Sequences tr_S2JX37_S2JX37_MUCC1_1220926 and tr_A0A168JYY3_A0A168JYY3_MUCCL_747725 are exactly identical! WARNING: Sequences tr_U5H8H0_U5H8H0_USTV1_683840 and tr_A0A2X0MK36_A0A2X0MK36_9BASI_796604 are exactly identical! WARNING: Sequences tr_V2XGQ0_V2XGQ0_MONRO_1381753 and tr_A0A0W0F8N7_A0A0W0F8N7_9AGAR_221103 are exactly identical! WARNING: Sequences tr_A0A3B6ELC4_A0A3B6ELC4_WHEAT_4565 and tr_A0A3B6H0I7_A0A3B6H0I7_WHEAT_4565 are exactly identical! WARNING: Sequences tr_A0A015L8J5_A0A015L8J5_9GLOM_1432141 and tr_A0A2H5U7U0_A0A2H5U7U0_RHIID_747089 are exactly identical! WARNING: Sequences tr_A0A015LM07_A0A015LM07_9GLOM_1432141 and tr_A0A2H5S1K3_A0A2H5S1K3_RHIID_747089 are exactly identical! WARNING: Sequences tr_A0A096NFW6_A0A096NFW6_PAPAN_9555 and tr_A0A0D9QWK9_A0A0D9QWK9_CHLSB_60711 are exactly identical! WARNING: Sequences tr_A0A096NFW6_A0A096NFW6_PAPAN_9555 and tr_A0A2K5ZWQ0_A0A2K5ZWQ0_MANLE_9568 are exactly identical! WARNING: Sequences tr_A0A2I3NIG6_A0A2I3NIG6_PAPAN_9555 and tr_A0A2K6CFA3_A0A2K6CFA3_MACNE_9545 are exactly identical! WARNING: Sequences tr_A0A2I3NIG6_A0A2I3NIG6_PAPAN_9555 and tr_A0A2K5XBU2_A0A2K5XBU2_MANLE_9568 are exactly identical! WARNING: Sequences tr_V4VDL5_V4VDL5_9ROSI_85681 and tr_A0A2H5PEE6_A0A2H5PEE6_CITUN_55188 are exactly identical! WARNING: Sequences tr_A0A0F0IN99_A0A0F0IN99_ASPPU_1403190 and tr_A0A2G7GBN1_A0A2G7GBN1_9EURO_656916 are exactly identical! WARNING: Sequences tr_A0A151MPF2_A0A151MPF2_ALLMI_8496 and tr_A0A1U7STY6_A0A1U7STY6_ALLSI_38654 are exactly identical! WARNING: Sequences tr_A0A0V1DDP6_A0A0V1DDP6_TRIBR_45882 and tr_A0A0V0VML3_A0A0V0VML3_9BILA_181606 are exactly identical! WARNING: Sequences tr_A0A164UDK3_A0A164UDK3_9HOMO_1314777 and tr_A0A166HCC8_A0A166HCC8_9HOMO_1314776 are exactly identical! WARNING: Sequences tr_A0A1S3WXG3_A0A1S3WXG3_TOBAC_4097 and tr_A0A1U7W268_A0A1U7W268_NICSY_4096 are exactly identical! WARNING: Sequences tr_A0A1S3XIH4_A0A1S3XIH4_TOBAC_4097 and tr_A0A1U7Y3N0_A0A1U7Y3N0_NICSY_4096 are exactly identical! WARNING: Sequences tr_A0A1S3ZD90_A0A1S3ZD90_TOBAC_4097 and sp_P08509_NIA2_TOBAC_4097 are exactly identical! WARNING: Sequences tr_A0A1S3ZD90_A0A1S3ZD90_TOBAC_4097 and tr_A0A1U7UPF8_A0A1U7UPF8_NICSY_4096 are exactly identical! WARNING: Sequences tr_A0A1S4CXQ4_A0A1S4CXQ4_TOBAC_4097 and sp_P11605_NIA1_TOBAC_4097 are exactly identical! WARNING: Sequences tr_A0A1S3H921_A0A1S3H921_LINUN_7574 and tr_A0A1S3HBR6_A0A1S3HBR6_LINUN_7574 are exactly identical! WARNING: Sequences tr_A0A1S3U449_A0A1S3U449_VIGRR_3916 and tr_A0A3Q0EXC1_A0A3Q0EXC1_VIGRR_3916 are exactly identical! WARNING: Sequences tr_A0A1U8F6Y1_A0A1U8F6Y1_CAPAN_4072 and tr_A0A2G3BGV2_A0A2G3BGV2_CAPCH_80379 are exactly identical! WARNING: Duplicate sequences found: 53 NOTE: Reduced alignment (with duplicates and gap-only sites/taxa removed) NOTE: was saved to: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P00387/4_raxmlng_ancestral/P00387.raxml.reduced.phy Alignment comprises 1 partitions and 301 sites Partition 0: noname Model: LG4X+R4 Alignment sites: 301 Gaps: 8.99 % Invariant sites: 1.00 % NOTE: Binary MSA file created: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P00387/4_raxmlng_ancestral/P00387.raxml.rba Parallelization scheme autoconfig: 1 worker(s) x 4 thread(s) Parallel reduction/worker buffer size: 1 KB / 0 KB [00:00:00] Loading user starting tree(s) from: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P00387/3_mltree/P00387.raxml.bestTree_unrooted [00:00:00] Data distribution: max. partitions/sites/weight per thread: 1 / 76 / 6080 [00:00:00] Data distribution: max. searches per worker: 1 Starting ML tree search with 1 distinct starting trees [00:00:00] Tree #1, initial LogLikelihood: -146104.473105 [00:00:00 -146104.473105] Initial branch length optimization [00:00:00 -144141.326501] Model parameter optimization (eps = 0.100000) [00:00:24] Tree #1, final logLikelihood: -143794.572391 Optimized model parameters: Partition 0: noname Rate heterogeneity: FREE (4 cats, mean), weights&rates: (0.168332,0.252271) (0.247439,0.400482) (0.339319,1.047384) (0.244910,2.053991) Base frequencies (model): M0: 0.147383 0.017579 0.058208 0.017707 0.026331 0.041582 0.017494 0.027859 0.011849 0.076971 0.147823 0.019535 0.037132 0.029940 0.008059 0.088179 0.089653 0.006477 0.032308 0.097931 M1: 0.063139 0.066357 0.011586 0.066571 0.010800 0.009276 0.053984 0.146986 0.034214 0.088822 0.098196 0.032390 0.021263 0.072697 0.016761 0.020711 0.020797 0.025463 0.045615 0.094372 M2: 0.062457 0.066826 0.049332 0.065270 0.006513 0.041231 0.058965 0.080852 0.028024 0.037024 0.075925 0.064131 0.019620 0.028710 0.104579 0.056388 0.062027 0.008241 0.033124 0.050760 M3: 0.106471 0.074171 0.044513 0.096390 0.002148 0.066733 0.158908 0.037625 0.020691 0.014608 0.028797 0.105352 0.007864 0.007477 0.083595 0.055726 0.047711 0.003975 0.010088 0.027159 Substitution rates (model): M 0: 0.295719 0.067388 0.253712 1.029289 0.107964 0.514644 10.868848 0.380498 0.084223 0.086976 0.188789 0.286389 0.155567 1.671061 2.132922 0.529591 0.115551 0.102453 0.916683 0.448317 0.457483 0.576016 1.741924 0.736017 0.704334 5.658311 0.123387 0.221777 93.433377 0.382175 0.235965 6.535048 0.525521 0.303537 0.641259 0.289466 0.102065 2.358429 0.251987 0.216561 0.503084 0.435271 4.873453 0.090748 0.033310 0.746537 0.128905 0.127321 0.904011 0.939733 0.435450 0.046646 0.262076 0.043986 0.189008 0.599450 109.901504 1.070052 5.229858 0.052764 0.021407 0.621146 0.081091 0.205164 5.164456 0.747330 0.308078 0.260889 0.185083 0.080708 0.029955 0.084794 1.862626 0.553477 0.151733 0.230320 0.096955 0.352526 0.590018 0.386853 1.559564 0.606648 0.587531 0.592318 0.885230 4.117654 0.246260 6.508329 0.054187 0.195703 1.669092 0.810168 0.066081 2.437439 0.165666 0.106333 0.093417 0.035149 0.072549 1.202023 1.634845 0.060194 0.069359 2.448827 0.232297 0.064822 3.537387 0.435384 0.290413 0.280695 0.105999 0.206603 0.404968 0.048984 0.069963 0.256662 0.228519 0.241077 4.320442 3.656545 0.290216 0.307466 0.096556 0.306067 0.204296 0.504221 1.991533 0.655465 6.799829 11.291065 0.961142 0.448965 6.227274 20.304886 0.205944 1.495537 0.091940 1.994320 0.754940 0.170343 0.050315 0.372166 0.206332 0.097050 5.381403 0.122332 3.256485 2.261319 0.848067 0.064441 0.102493 0.459041 0.133091 0.561215 0.457430 0.163849 5.260446 0.360946 0.389413 0.033291 0.115301 0.112593 1.559944 0.426508 0.132547 0.498634 0.559069 0.264728 0.693307 0.438856 0.306683 0.109129 18.392863 66.647302 0.400021 4.586081 2.099355 0.411347 0.476350 0.584622 3.634276 0.101797 0.148995 0.089177 0.034710 0.063603 0.755865 20.561407 0.133790 0.154902 M 1: 0.066142 0.590377 0.069930 9.850951 1.101363 0.150375 0.568586 0.051668 0.127170 0.292429 0.071458 1.218562 0.075144 7.169085 30.139501 13.461692 0.021372 0.045779 4.270235 0.468325 0.013688 0.302287 1.353957 0.028386 0.037750 0.262130 0.016923 0.064289 0.855973 0.079621 0.011169 0.161937 0.276530 0.161053 0.081472 0.036742 0.030342 2.851667 3.932151 8.159169 0.219934 0.421974 2.468752 0.344765 0.210724 1.172204 0.763553 0.082464 0.726566 11.149790 4.782635 0.058046 0.498072 0.258487 0.146882 0.249672 0.560142 0.046719 0.106259 0.003656 0.004200 0.014189 0.009876 0.002656 0.040244 0.267322 0.053740 0.006597 0.027639 0.012745 0.582670 0.005035 0.275844 0.098208 0.445038 1.217010 0.033969 1.988516 0.681161 0.825960 18.762977 11.949233 0.286794 0.534219 4.336817 3.054085 0.129551 4.210126 0.165753 1.088704 1.889645 3.344809 0.111063 2.067758 3.547017 2.466507 0.188236 0.203493 0.281953 0.037250 0.029788 0.008541 0.014768 0.125869 0.056702 0.004186 0.110993 0.201148 0.139705 0.009201 0.012095 0.043812 0.013513 0.002533 0.005848 0.031390 0.021612 0.004854 0.129497 0.976631 0.053397 0.019475 0.004964 0.015539 0.031779 0.064558 0.065585 0.079927 0.095591 0.196886 0.408834 0.126088 0.037226 0.452302 0.016212 7.278994 0.029917 7.918203 0.450964 0.169797 0.104288 1.578530 0.015909 0.094365 16.179952 0.042762 14.799537 1.506485 0.637893 0.123793 0.641351 0.154810 0.140750 3.416059 0.259400 0.009457 0.090576 0.292108 0.297913 0.017172 0.021976 0.032578 1.375871 0.457399 0.598048 4.418398 0.239749 0.168432 2.950318 0.143327 0.328689 0.125011 0.562720 1.414883 0.227807 3.478333 2.984862 0.061299 0.077470 1.050562 13.974326 0.154326 0.224675 0.112000 0.060703 0.123480 5.294490 0.447011 0.033381 0.045528 M 2: 0.733336 0.558955 0.503360 4.149599 1.415369 1.367574 1.263002 0.994098 0.517204 0.775054 0.763094 1.890137 0.540460 0.200122 4.972745 1.825593 0.450842 0.526135 3.839269 0.597671 0.058964 2.863355 2.872594 0.258365 0.366868 2.578946 0.358350 0.672023 5.349861 0.691594 0.063347 0.032875 0.821562 0.580847 0.661866 0.265730 0.395134 5.581680 1.279881 1.335650 0.397108 1.840061 5.739035 0.284730 0.109781 1.612642 0.466979 0.141582 0.019509 4.670980 1.967383 0.088064 0.581928 0.145401 0.225860 0.434096 2.292917 1.024707 0.821921 0.027824 0.021443 0.088850 0.060820 0.018288 0.042687 1.199607 0.420710 0.037642 0.141233 0.090101 1.043232 0.209978 0.823594 3.039380 1.463390 1.983693 0.397640 2.831098 4.102068 0.059723 5.901348 2.034980 2.600668 5.413080 4.193725 4.534772 0.377181 4.877840 0.370939 1.298542 3.509873 2.646440 0.087872 0.072299 1.139018 0.864479 0.390688 0.322761 0.625409 0.496780 0.532488 0.232460 0.169219 0.755219 0.379926 0.020447 0.023282 0.503875 0.577513 0.109318 0.153776 0.696533 0.398817 0.008940 0.043707 0.436013 0.087640 0.064863 0.036426 1.673207 0.124068 0.218118 0.039217 0.104335 0.349195 0.838324 0.888693 0.488389 1.385133 0.050226 0.962470 0.502294 1.065585 8.351808 0.377304 5.102837 0.561690 7.010411 3.054968 0.039318 0.204155 2.653232 0.564368 0.854294 15.559906 0.401070 8.929538 5.525874 0.067505 0.273372 0.437116 1.927515 0.940458 2.508169 1.357738 0.043394 0.023126 0.567639 1.048288 0.120994 0.180650 0.449074 3.135353 0.012695 0.570771 2.319555 1.856122 0.975427 3.404087 0.015631 0.458799 0.151684 4.154750 11.429924 1.457957 0.233109 0.077004 0.011074 0.026268 0.052132 8.113282 0.377578 0.429221 0.260296 0.222293 0.273138 2.903836 4.731579 0.564762 0.681215 M 3: 0.658412 0.566269 0.854111 0.884454 1.309554 1.272639 1.874713 0.552007 0.227683 0.581512 0.695190 0.967985 0.344015 0.978992 3.427163 2.333253 0.154701 0.221089 2.088785 0.540749 0.058015 5.851132 2.294145 0.182966 0.684164 3.192521 0.528161 1.128882 3.010922 1.012866 0.227296 0.156635 0.878405 0.802754 0.830884 0.431617 0.456530 3.060574 1.279257 1.438430 0.431464 2.075952 4.840271 0.644656 0.266076 2.084975 0.720060 0.291854 0.028961 4.071574 2.258357 0.073037 1.238426 0.199728 0.160296 0.482619 2.992763 1.296206 0.841829 0.031467 0.048542 0.132774 0.133055 0.056045 0.209188 0.925172 0.360522 0.094591 0.313945 0.118104 0.992259 0.086318 2.149634 5.103188 3.775817 3.954021 0.190734 1.776095 4.495841 0.264277 7.063879 2.221150 3.017954 8.558815 4.310199 2.130054 0.571406 4.137385 0.437589 2.071689 2.498630 1.763546 0.116381 0.296578 1.033710 1.283423 0.312579 0.305772 0.681277 0.507160 0.351381 0.189152 0.217780 0.767361 0.278392 0.092075 0.177263 0.451893 0.653836 0.074620 0.181992 0.752277 0.679853 0.025780 0.082005 0.326441 0.343977 0.195877 0.217424 3.057583 0.377558 0.401252 0.072258 0.241015 0.665865 1.266791 0.680174 0.717301 4.001286 0.362942 1.189259 0.964545 1.350568 12.869737 0.531100 8.904999 0.652629 10.091413 2.671718 0.086367 0.359932 4.797423 0.336801 1.021885 23.029406 0.440178 14.013035 5.069337 0.539010 0.742569 0.780580 1.331875 1.531589 4.414850 1.082703 0.091278 0.172734 0.693405 1.422571 0.068958 0.163829 0.481711 4.643214 0.121821 0.584083 4.216178 1.677263 1.575754 5.046403 0.161015 1.531223 0.599244 5.832025 33.873091 1.914768 1.287474 0.444362 0.076328 0.079916 0.466823 5.231362 0.548763 0.831890 0.382271 0.208791 0.307846 3.717971 5.910440 0.282540 0.964421 Marginal ancestral probabilities saved to: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P00387/4_raxmlng_ancestral/P00387.raxml.ancestralProbs Reconstructed ancestral sequences saved to: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P00387/4_raxmlng_ancestral/P00387.raxml.ancestralStates Node-labeled tree saved to: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P00387/4_raxmlng_ancestral/P00387.raxml.ancestralTree Execution log saved to: /cta/users/eakkoyun/WORKFOLDER/PROD/run_020621/phylogeny-snakemake/results/P00387/4_raxmlng_ancestral/P00387.raxml.log Analysis started: 04-Jun-2021 14:18:46 / finished: 04-Jun-2021 14:19:13 Elapsed time: 27.217 seconds